ea0021p186 | Diabetes and metabolism | SFEBES2009
Harno Erika
, Yu Alice
, Brown Henry
, Turnbull Andrew
, Leighton Brendan
, White Anne
Increased corticosterone (cortisol in humans) in liver has important adverse effects on glucose metabolism and is therefore a target for diabetes treatments. The functional effects of corticosterone depend on circulating levels as well as tissue regeneration by 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) and inactivation by steroid 5-α-reductase type I (5αR). This study investigates how obesity affects diurnal changes in circulating corticosterone, the ge...